Kezidime®

Therapeutic Segment:
Anti-biotic

Generic Name:
Ceftazidime

Description:
Ceftazidime is a semisynthetic, broad-spectrum, beta-lactam antibacterial drug for parenteral administration.

Indication:

After intramuscular administration of 500 mg and 1 g of ceftazidime, peak plasma levels of 18 and 37 mg/l, respectively, are achieved rapidly. Five minutes after intravenous bolus injection of 500 mg, 1 g or 2 g, plasma levels are 46, 87 and 170 mg/l, respectively. Distribution: The serum protein binding is low at about 10%. Concentrations in excess of the MIC for common pathogens can be achieved in tissues such as bone, heart, bile, sputum, aqueous humour, synovial, pleural and peritoneal fluids. Ceftazidime crosses the placenta readily, and is excreted in the breast milk. Penetration of the intact blood-brain barrier is poor, resulting in low levels of ceftazidime in the CSF in the absence of inflammation. However, concentrations of 4 to 20 mg/l or more are achieved in the CSF when the meninges are inflamed. Biotransformation: Ceftazidime is not metabolised. Elimination: After parenteral administration plasma levels decrease with a half-life of about 2 h. Ceftazidime is excreted unchanged into the urine; approximately 80 to 90% of the dose is recovered in the urine within 24 h. Less than 1% is excreted via the bile. Special patient populations Renal impairment: Elimination of ceftazidime is decreased in patients with impaired renal function and the dose should be reduced. Hepatic impairment: The presence of mild to moderate hepatic dysfunction had no effect on the pharmacokinetics of ceftazidime. Elderly: The reduced clearance observed in elderly patients. The mean elimination half-life ranged from 3.5 to 4 hours following single or 7 days repeat BID dosing of 2 g IV bolus injections in elderly patients 80 years or older. Paediatric population: The half-life of ceftazidime is prolonged in preterm and term neonates by 4.5 to 7.5 hours after doses of 25 to 30 mg/kg. However, by the age of 2 months the half-life is within the range for adults.

Formulation:

  • Injection

Strength:

  • 250mg
  • 500mg

Pack Size:

  • 1’s
  • 1’s